Residential delivery area · Wisconsin
ZIP Code 53221: Milwaukee, WI
ZIP code 53221 is in Milwaukee, Wisconsin, entirely in Milwaukee County (Census 2020 ZIP-county file). About 38,000 people live there (Census Bureau, ACS 2020-2024), the 5th most populous of Milwaukee's 29 residential ZIP codes. Median household income is $63,265 (Census Bureau, ACS 2020-2024). By Census place, its land lies in Milwaukee (69%) and Greenfield (30%), and 1% in smaller places.
- ACS2020-24
- Census2020
- FHFA2025
- ZBP2023
- IRS2022
- Town
- Milwaukee · 29 residential ZIPs
- County
- Milwaukee County
- Census places
- Milwaukee (69%); Greenfield (30%)
- Metro area
- Milwaukee-Waukesha, WI
- House districts
- WI-4 (69%), WI-5 (30%), WI-1 (1%) 119th Congress, by share of land
- State
- Wisconsin
- Time zone
- Central
- Land area
- 9.0 sq mi · 4,223 people per sq mi
- PO Box ZIPs
- 12 more ZIP codes use the name Milwaukee for PO boxes or single organizations
Where is ZIP code 53221?
53221 centers on 42.954°, -87.943° and covers 9.0 square miles of land plus 0.0 of water. It borders 7 ZIP codes: 53220, 53207, 53129, 53215, 53219, 53154, 53132.
The map draws ZIP code areas only. For the streets inside 53221, open its center on OpenStreetMap.
Source: U.S. Census Bureau, 2020 ZCTA cartographic boundaries and the 2023 Gazetteer (2020 ZCTAs); ZIP-to-county shares, Census places and House districts (119th Congress) from the Census 2020 relationship files (shares of land); metro area from the OMB delineation (July 2023); town name and time zone from simplemaps US ZIP Codes (CC BY 4.0).
How does 53221 compare with the rest of Milwaukee?
| Measure | 53221 | In Milwaukee | In WI |
|---|---|---|---|
| People (ACS 2020-2024) | 38,044 | 5th of 29 | 20th of 783 |
| Median household income | $63k | 14th of 28 | 516th of 610 |
| Median home value | $220k | 10th of 25 | 396th of 612 |
Its median household income is higher than in 35% of U.S. residential ZIP codes, and it is denser than 92% of all U.S. residential ZIP codes. ZIP codes at the ACS caps ($250,000 or more for household income, $2,000,000 or more for home value) share the top rank.
Source: U.S. Census Bureau, ACS 2020-2024 5-year estimates (B01003, B19013, B25077); ranks by PlainZIP over residential ZIP codes (ZCTAs).
How many people live in 53221?
The 2020 Census counted 39,560 people in 53221; the ACS, which samples households over 2020-2024, estimates 38,044. Between the 2010 and 2020 censuses its population grew 4.9% (its boundary stayed at least 90% the same).
- People, ACS 2020-2024
- 38,044
- 2020 Census count
- 39,560+4.9% since 2010 (37,701)
- Households
- 16,293
- Median age
- 38.8
Source: U.S. Census Bureau, ACS 2020-2024 5-year estimates (B01003, B01002, B11001); 2020 Census (DHC P1); 2010 Census (SF1 P1).
Who lives in 53221?
Of the 38,044 people the ACS estimates in 53221, 23.2% are under 18 and 15.9% are 65 or older. The largest group by race and Hispanic origin is White (not Hispanic) (52.8%), then Hispanic or Latino (25.8%).
- Under 1823.2%
- 18 to 6460.9%
- 65 and older15.9%
- White, not Hispanic52.8%
- Hispanic or Latino25.8%
- Asian, not Hispanic7.7%
- Black, not Hispanic7.0%
- Other or two or more6.6%
Source: U.S. Census Bureau, ACS 2020-2024 5-year estimates (B01001 age by sex, B03002 Hispanic or Latino origin by race); shares of the estimated population, small ZIP codes carry wide margins.
What do households in 53221 earn?
Median household income is $63,265 (ACS 2020-2024), the 14th highest of the 28 ranked ZIP codes in Milwaukee. It is not measurably different from 2015-2019 ($63,642 in 2024 dollars): the change is within the surveys' margins of error.
- Median household income
- $63,265
- Income per person
- $35,103
- Below the poverty line
- 14.6%
- Unemployed (of the labor force)
- 3.7%
- Adults 25+ with a bachelor's degree
- 24.7%
- Adjusted gross income per tax return, 2022
- $55,82619,000 returns; wages 73% of AGI (IRS)
Source: U.S. Census Bureau, ACS 2020-2024 and 2015-2019 5-year estimates (B19013, B19301, B17001, B23025, B15003; 2015-2019 dollars converted with the BLS CPI-U, 1.22699); IRS Statistics of Income, ZIP code data, tax year 2022 (adjusted gross income per return, filed under the address on the return).
What are homes worth in 53221?
FHFA's house price index for 53221, built from repeat sales and appraisals of the same homes, rose 107% from 2015 to 2025 and rose 58% from 2020 to 2025, and moved +7.2% in 2025.
- Median home value (owners' estimate)
- $219,600
- Median gross rent
- $1,119
- Homes owned by their occupants
- 56.9%
- Housing units
- 16,865
Source: U.S. Census Bureau, ACS 2020-2024 5-year estimates (B25077, B25064, B25003, B25001); FHFA House Price Index, annual five-digit ZIP, updated 2026-03-31.
What businesses are in 53221?
635 business establishments had a location in this ZIP code in 2023, 26 more than in 2018; the most are in retail trade (ZIP Code Business Patterns).
- Retail trade116
- Health care and social assistance95
- Accommodation and food services83
- Other services (except public administration)60
- Transportation and warehousing54
- Construction52
Source: U.S. Census Bureau, ZIP Code Business Patterns 2023 and 2018 (establishments with paid employees, by the business's ZIP code).
Which ZIP codes are next to 53221?
| ZIP | Town | People | Household income | Distance |
|---|---|---|---|---|
| 53220 | Milwaukee | 27,782 | $69k | 2.5 mi |
| 53207 | Milwaukee | 34,313 | $79k | 2.7 mi |
| 53129 | Greendale | 14,570 | $95k | 3.1 mi |
| 53215 | Milwaukee | 58,146 | $54k | 3.1 mi |
| 53219 | Milwaukee | 34,764 | $70k | 3.8 mi |
| 53154 | Oak Creek | 37,325 | $97k | 5.7 mi |
| 53132 | Franklin | 35,433 | $110k | 5.8 mi |
| 53235 | Saint Francis | 9,004 | $57k | 4.0 mi (near) |
| 53110 | Cudahy | 17,853 | $67k | 4.2 mi (near) |
| 53204 | Milwaukee | 39,996 | $46k | 4.6 mi (near) |
Source: PlainZIP from the Census 2020 ZCTA boundaries (shared edges) and internal points; figures ACS 2020-2024.