Residential delivery area · Ohio
ZIP Code 45601: Chillicothe, OH
ZIP code 45601 uses the postal name Chillicothe, Ohio and lies mostly in Ross County (94% of its land), reaching into Pike County and Jackson County (Census 2020 ZIP-county file). About 56,000 people live there (Census Bureau, ACS 2020-2024). Median household income is $59,748 (Census Bureau, ACS 2020-2024). By Census place, its land lies in Chillicothe (3%), Andersonville (under 1%) and Massieville (under 1%); 96% is outside any Census place.
- ACS2020-24
- Census2020
- FHFA2025
- ZBP2023
- IRS2022
- Town
- Chillicothe · its only residential ZIP
- County
- Ross County (94%); Pike County (3%); Jackson County (3%)
- Census places
- Chillicothe (3%); Andersonville (under 1%) census-designated place; Massieville (under 1%) census-designated place
- Micro area
- Chillicothe, OH
- House district
- OH-2 119th Congress
- State
- Ohio
- Time zone
- Eastern
- Land area
- 348.7 sq mi · 160 people per sq mi
Where is ZIP code 45601?
45601 centers on 39.312°, -82.957° and covers 348.7 square miles of land plus 3.3 of water. It borders 12 ZIP codes: 45673, 45617, 45644, 45647, 45690, 45628, 45681, 43115, 45672, 43135 and more.
The map draws ZIP code areas only. For the streets inside 45601, open its center on OpenStreetMap.
Source: U.S. Census Bureau, 2020 ZCTA cartographic boundaries and the 2023 Gazetteer (2020 ZCTAs); ZIP-to-county shares, Census places and House districts (119th Congress) from the Census 2020 relationship files (shares of land); metro area from the OMB delineation (July 2023); town name and time zone from simplemaps US ZIP Codes (CC BY 4.0).
How does 45601 compare with the rest of Ross County?
| Measure | 45601 | In Ross County | In OH |
|---|---|---|---|
| People (ACS 2020-2024) | 55,836 | 1st of 15 | 20th of 1,233 |
| Median household income | $60k | 6th of 9 | 568th of 755 |
| Median home value | $173k | 5th of 9 | 496th of 810 |
Its median household income is higher than in 29% of U.S. residential ZIP codes, and it is denser than 60% of all U.S. residential ZIP codes. ZIP codes at the ACS caps ($250,000 or more for household income, $2,000,000 or more for home value) share the top rank.
Source: U.S. Census Bureau, ACS 2020-2024 5-year estimates (B01003, B19013, B25077); ranks by PlainZIP over residential ZIP codes (ZCTAs).
How many people live in 45601?
The 2020 Census counted 56,849 people in 45601; the ACS, which samples households over 2020-2024, estimates 55,836. Between the 2010 and 2020 censuses its population fell 1.7% (its boundary stayed at least 90% the same).
- People, ACS 2020-2024
- 55,836
- 2020 Census count
- 56,849−1.7% since 2010 (57,842)
- Households
- 21,678
- Median age
- 41.5
Source: U.S. Census Bureau, ACS 2020-2024 5-year estimates (B01003, B01002, B11001); 2020 Census (DHC P1); 2010 Census (SF1 P1).
Who lives in 45601?
Of the 55,836 people the ACS estimates in 45601, 19.8% are under 18 and 17.9% are 65 or older. The largest group by race and Hispanic origin is White (not Hispanic) (85.7%).
- Under 1819.8%
- 18 to 6462.3%
- 65 and older17.9%
- White, not Hispanic85.7%
- Black, not Hispanic7.3%
- Other or two or more4.6%
- Hispanic or Latino1.7%
- Asian, not Hispanic0.6%
Source: U.S. Census Bureau, ACS 2020-2024 5-year estimates (B01001 age by sex, B03002 Hispanic or Latino origin by race); shares of the estimated population, small ZIP codes carry wide margins.
What do households in 45601 earn?
Median household income is $59,748 (ACS 2020-2024), the 6th highest of the 9 ranked ZIP codes in Ross County. It is not measurably different from 2015-2019 ($60,925 in 2024 dollars): the change is within the surveys' margins of error.
- Median household income
- $59,748
- Income per person
- $32,494
- Below the poverty line
- 17.0%
- Unemployed (of the labor force)
- 4.0%
- Adults 25+ with a bachelor's degree
- 18.1%
- Adjusted gross income per tax return, 2022
- $61,48824,080 returns; wages 70% of AGI (IRS)
Source: U.S. Census Bureau, ACS 2020-2024 and 2015-2019 5-year estimates (B19013, B19301, B17001, B23025, B15003; 2015-2019 dollars converted with the BLS CPI-U, 1.22699); IRS Statistics of Income, ZIP code data, tax year 2022 (adjusted gross income per return, filed under the address on the return).
What are homes worth in 45601?
FHFA's house price index for 45601, built from repeat sales and appraisals of the same homes, rose 86% from 2015 to 2025 and rose 51% from 2020 to 2025, and moved +3.1% in 2025.
- Median home value (owners' estimate)
- $173,100
- Median gross rent
- $915
- Homes owned by their occupants
- 67.8%
- Housing units
- 23,192
Source: U.S. Census Bureau, ACS 2020-2024 5-year estimates (B25077, B25064, B25003, B25001); FHFA House Price Index, annual five-digit ZIP, updated 2026-03-31.
What businesses are in 45601?
1,070 business establishments had a location in this ZIP code in 2023, 6 more than in 2018; the most are in retail trade (ZIP Code Business Patterns).
- Retail trade217
- Health care and social assistance150
- Accommodation and food services124
- Other services (except public administration)120
- Construction66
- Finance and insurance61
Source: U.S. Census Bureau, ZIP Code Business Patterns 2023 and 2018 (establishments with paid employees, by the business's ZIP code).
Which ZIP codes are next to 45601?
| ZIP | Town | People | Household income | Distance |
|---|---|---|---|---|
| 45673 | Richmond Dale | 473 | $64k | 10.8 mi |
| 45617 | Bourneville | 0 | – | 10.8 mi |
| 45644 | Kingston | 4,619 | $74k | 11.4 mi |
| 45647 | Londonderry | 1,869 | $70k | 12.0 mi |
| 45690 | Waverly | 13,988 | $54k | 12.1 mi |
| 45628 | Frankfort | 5,999 | $73k | 13.7 mi |
| 45681 | South Salem | 1,451 | $50k | 16.1 mi |
| 43115 | Clarksburg | 1,796 | $94k | 16.7 mi |
| 45672 | Ray | 1,361 | $49k | 16.8 mi |
| 43135 | Laurelville | 3,937 | $73k | 17.1 mi |
| 45612 | Bainbridge | 4,933 | $54k | 18.7 mi |
| 43113 | Circleville | 24,480 | $67k | 19.0 mi |
Source: PlainZIP from the Census 2020 ZCTA boundaries (shared edges) and internal points; figures ACS 2020-2024.