Residential delivery area · Michigan
ZIP Code 49221: Adrian, MI
ZIP code 49221 uses the postal name Adrian, Michigan and lies entirely in Lenawee County (Census 2020 ZIP-county file). About 41,000 people live there (Census Bureau, ACS 2020-2024). Median household income is $65,977 (Census Bureau, ACS 2020-2024). By Census place, 7% of its land lies in Adrian; 93% is outside any Census place.
- ACS2020-24
- Census2020
- FHFA2025
- ZBP2023
- IRS2022
- Town
- Adrian · its only residential ZIP
- County
- Lenawee County
- Census places
- Adrian
- Micro area
- Adrian, MI
- House district
- MI-5 119th Congress
- State
- Michigan
- Time zone
- Eastern
- Land area
- 119.9 sq mi · 343 people per sq mi
Where is ZIP code 49221?
49221 centers on 41.902°, -84.065° and covers 119.9 square miles of land plus 0.7 of water. It borders 9 ZIP codes: 49268, 49235, 49287, 49279, 49265, 49286, 49248, 49253, 49229.
The map draws ZIP code areas only. For the streets inside 49221, open its center on OpenStreetMap.
Source: U.S. Census Bureau, 2020 ZCTA cartographic boundaries and the 2023 Gazetteer (2020 ZCTAs); ZIP-to-county shares, Census places and House districts (119th Congress) from the Census 2020 relationship files (shares of land); metro area from the OMB delineation (July 2023); town name and time zone from simplemaps US ZIP Codes (CC BY 4.0).
How does 49221 compare with the rest of Lenawee County?
| Measure | 49221 | In Lenawee County | In MI |
|---|---|---|---|
| People (ACS 2020-2024) | 41,087 | 1st of 22 | 31st of 992 |
| Median household income | $66k | 14th of 17 | 465th of 774 |
| Median home value | $170k | 14th of 18 | 521st of 779 |
Its median household income is higher than in 40% of U.S. residential ZIP codes, and it is denser than 68% of all U.S. residential ZIP codes. ZIP codes at the ACS caps ($250,000 or more for household income, $2,000,000 or more for home value) share the top rank.
Source: U.S. Census Bureau, ACS 2020-2024 5-year estimates (B01003, B19013, B25077); ranks by PlainZIP over residential ZIP codes (ZCTAs).
How many people live in 49221?
The 2020 Census counted 41,315 people in 49221; the ACS, which samples households over 2020-2024, estimates 41,087. Between the 2010 and 2020 censuses its population grew 0.0% (its boundary stayed at least 90% the same).
- People, ACS 2020-2024
- 41,087
- 2020 Census count
- 41,315+0.0% since 2010 (41,310)
- Households
- 15,658
- Median age
- 41.1
Source: U.S. Census Bureau, ACS 2020-2024 5-year estimates (B01003, B01002, B11001); 2020 Census (DHC P1); 2010 Census (SF1 P1).
Who lives in 49221?
Of the 41,087 people the ACS estimates in 49221, 19.1% are under 18 and 19.9% are 65 or older. The largest group by race and Hispanic origin is White (not Hispanic) (77.0%), then Hispanic or Latino (13.8%).
- Under 1819.1%
- 18 to 6461.0%
- 65 and older19.9%
- White, not Hispanic77.0%
- Hispanic or Latino13.8%
- Black, not Hispanic4.7%
- Other or two or more4.3%
- Asian, not Hispanic0.2%
Source: U.S. Census Bureau, ACS 2020-2024 5-year estimates (B01001 age by sex, B03002 Hispanic or Latino origin by race); shares of the estimated population, small ZIP codes carry wide margins.
What do households in 49221 earn?
Median household income is $65,977 (ACS 2020-2024), the 14th highest of the 17 ranked ZIP codes in Lenawee County. It rose from $58,837 in 2015-2019 (in 2024 dollars), a change larger than the surveys' margins of error.
- Median household income
- $65,977
- Income per person
- $31,437
- Below the poverty line
- 15.5%
- Unemployed (of the labor force)
- 4.5%
- Adults 25+ with a bachelor's degree
- 22.3%
- Adjusted gross income per tax return, 2022
- $56,56017,180 returns; wages 70% of AGI (IRS)
Source: U.S. Census Bureau, ACS 2020-2024 and 2015-2019 5-year estimates (B19013, B19301, B17001, B23025, B15003; 2015-2019 dollars converted with the BLS CPI-U, 1.22699); IRS Statistics of Income, ZIP code data, tax year 2022 (adjusted gross income per return, filed under the address on the return).
What are homes worth in 49221?
FHFA's house price index for 49221, built from repeat sales and appraisals of the same homes, rose 99% from 2015 to 2025 and rose 49% from 2020 to 2025, and moved +5.9% in 2025.
- Median home value (owners' estimate)
- $170,400
- Median gross rent
- $992
- Homes owned by their occupants
- 71.1%
- Housing units
- 17,187
Source: U.S. Census Bureau, ACS 2020-2024 5-year estimates (B25077, B25064, B25003, B25001); FHFA House Price Index, annual five-digit ZIP, updated 2026-03-31.
What businesses are in 49221?
819 business establishments had a location in this ZIP code in 2023, 22 fewer than in 2018; the most are in retail trade (ZIP Code Business Patterns).
- Retail trade138
- Health care and social assistance134
- Other services (except public administration)90
- Accommodation and food services86
- Construction67
- Finance and insurance56
Source: U.S. Census Bureau, ZIP Code Business Patterns 2023 and 2018 (establishments with paid employees, by the business's ZIP code).
Which ZIP codes are next to 49221?
| ZIP | Town | People | Household income | Distance |
|---|---|---|---|---|
| 49268 | Palmyra | 1,108 | $81k | 7.4 mi |
| 49235 | Clayton | 2,115 | $64k | 7.5 mi |
| 49287 | Tipton | 1,958 | $88k | 8.4 mi |
| 49279 | Sand Creek | 965 | $71k | 8.7 mi |
| 49265 | Onsted | 5,157 | $78k | 9.2 mi |
| 49286 | Tecumseh | 14,128 | $72k | 10.1 mi |
| 49248 | Jasper | 787 | $81k | 10.4 mi |
| 49253 | Manitou Beach | 3,009 | $89k | 11.3 mi |
| 49229 | Britton | 3,540 | $95k | 13.7 mi |
| 49289 | Weston | 129 | – | 9.3 mi (near) |
Source: PlainZIP from the Census 2020 ZCTA boundaries (shared edges) and internal points; figures ACS 2020-2024.