ZIP Code 49221

standard

Source:

Adrian · Lenawee County · Michigan

Population
41,310

135/sq mi

Median income
$65,977

▼ 14% vs US

higher than 40% of US ZIPs

Median home value
$170,400

▼ 39% vs US

higher than 34% of US ZIPs

Bachelor's or higher
22.3%

Median age 41.1

Land area
306.7 sq mi

Detroit

ZIP code 49221 in Adrian, Michigan has a population of 41,310. The median household income is $65,977, which is 14% below the national average. Median home value is $170,400, 39% below the US average. 22.3% of residents hold a bachelor's degree or higher.

ZIP code 49221 is classified by USPS as a standard delivery area and covers roughly 306.7 square miles in Adrian, Lenawee County, Michigan. The area is home to 41,310 residents, producing a population density of 135 people per square mile, and falls within the Detroit time zone. These USPS and Census boundary values drive every downstream statistic on this page, including the benchmarks that compare 49221 against Michigan and the nation.

On the economic side, the median household income for ZIP 49221 sits at $65,977 (10% below the Michigan average), while per-capita income is $31,437. The poverty rate stands at 15.5% and the unemployment rate at 4.5%. On housing, the median home value is $170,400 (22% below the state average) with median rent at $992 per month, and 71.1% of occupied units are owner-occupied, a direct signal of whether 49221 behaves more like a homeowner neighborhood or a renter-heavy ZIP.

Education and household profile round out the picture: 22.3% of adults hold a bachelor's degree or higher, the median age is 41.1, and the average commute is 24 minutes. We also surface 7 nearby ZIP codes within roughly 10 miles and 6 additional ZIPs sharing Lenawee County, so you can benchmark 49221 against its immediate geography rather than a national average alone. Every figure is sourced from the U.S. Census Bureau American Community Survey 5-Year Estimates, HUD Fair Market Rents, and FHFA Home Price Index data, no estimates, no proprietary scoring. Verify with HUD →

Top industries in ZIP 49221

Top 5 sectors by establishment count

Which industries have the most business establishments in ZIP 49221.

establishments

What this shows Establishment counts come from the Census ZIP Code Business Patterns program, which counts physical business locations rather than employees or revenue.

Source U.S. Census Bureau · ZIP Code Business Patterns (ZBP) As of 2023

Source: U.S. Census Bureau, American Community Survey 5-Year Estimates + ZIP Code Business Patterns + HUD FMR + FHFA HPI ACS demographics, ZBP business establishments, HUD Fair Market Rents, FHFA HPI for ZIP 49221, Adrian, MI · 2023 Census ACS 5-Year Estimates use a rolling 60-month sample for stable small-geography estimates; ZBP updated annually; HUD FMR + FHFA HPI updated quarterly/annually.

Quick Facts

41,310

Population

306.7

Area (sq mi)

135

People / sq mi

Detroit

Time Zone

standard

ZIP Type

Neighborhood Scorecard
Get an A-F grade across income, safety, housing, rent, education, commute, and childcare for this ZIP code.
View Scorecard →

Who lives in ZIP 49221?

41.1

Median Age

51.9%

Male

48.1%

Female

2.7%

Foreign-Born

White 81.1%
African American 4.9%
Asian 0.3%
American Indian or Alaska Native 0.4%
Native Hawaiian or Pacific Islander 0.0%
Two or More Ethnicities 9.7%
Hispanic or Latino 13.8%

Hispanic or Latino is an ethnicity category from the Census Bureau and may overlap with other categories above.

Source: U.S. Census Bureau, ACS 5-Year Estimates (2023)

How much do residents earn?

$65,977

Median Household Income

-10% vs state

$31,437

Per Capita Income

15.5%

Poverty Rate

4.5%

Unemployment Rate

23.7 min

Mean Commute Time

Source: U.S. Census Bureau, ACS 5-Year Estimates (2023)

What is the education profile here?

High School Graduate or Higher 58.9%
Bachelor's Degree or Higher 22.3%

Source: U.S. Census Bureau, ACS 5-Year Estimates (2023)

What does housing look like?

17,187

Total Housing Units

15,658

Occupied Units

1,529

Vacant Units

2.34

Avg Household Size

Occupancy Type

Owner 71.1%
Renter 28.9%

$170,400

Median Home Value

-22% vs state

$992

Median Rent

1968

Median Year Built

Source: U.S. Census Bureau, ACS 5-Year Estimates (2023)

FHFA House Price Index, annual appreciation data based on repeat sales and appraisals

+4.8%

YoY Change (2024)

164

HPI Index (2000 = 100)

+64%

Total Change Since 2000

Home values in ZIP 49221 have increased 4.8% over the past year (2024). Since 2000, this ZIP has seen +64% cumulative appreciation.

Year Annual Change HPI Index
2020 +3.0% 118
2021 +13.6% 134
2022 +10.6% 148
2023 +6.1% 157
2024 +4.8% 164

Source: Federal Housing Finance Agency (FHFA) House Price Index, All-Transactions, Five-Digit ZIP Codes (Developmental Index). Index base = 100 in year 2000. Data through 2024. ZIP codes with few transactions may show missing values.

What businesses operate in this ZIP?

Census Bureau data shows 819 business establishments in ZIP 49221, employing approximately 14,453 people with a combined annual payroll of $671,869,000.

819

Businesses

14,453

Employees

$671.9M

Annual Payroll

17

Industry Sectors

Industry Establishments % of Total
Retail trade 138 16.9%
Health care and social assistance 134 16.4%
Other services (except public administration) 90 11.0%
Accommodation and food services 86 10.5%
Construction 67 8.2%
Finance and insurance 56 6.8%
Professional, scientific, and technical services 48 5.9%
Administrative and support and waste management and remediation services 45 5.5%
Real estate and rental and leasing 38 4.6%
Manufacturing 35 4.3%
Wholesale trade 21 2.6%
Transportation and warehousing 14 1.7%
Educational services 14 1.7%
Arts, entertainment, and recreation 11 1.3%
Information 10 1.2%
Management of companies and enterprises 5 0.6%
Utilities 3 0.4%

Source: U.S. Census Bureau, ZIP Code Business Patterns (ZBP), 2023. Employment figures may include noise for disclosure avoidance.

Nearby ZIP Codes

Want a side-by-side? Compare 49221 vs 49287 →

ZIP Code City Population Distance
49287 Tipton, MI 2,099 8.2 mi
49279 Sand Creek, MI 797 8.7 mi
49268 Palmyra, MI 1,059 7.4 mi
49289 Weston, MI 167 9.6 mi
49248 Jasper, MI 899 10.5 mi
49265 Onsted, MI 4,958 9.1 mi
49286 Tecumseh, MI 14,797 10.1 mi

More ZIP Codes in Lenawee County

Frequently Asked Questions

What county is ZIP code 49221 in?
ZIP code 49221 (Adrian) is located in Lenawee County, Michigan. Lenawee County contains multiple ZIP codes, see the full list at /counties/lenawee-mi.
What is the population of ZIP code 49221?
ZIP code 49221 in Adrian, MI has a population of 41,310 according to the Census Bureau ACS 2023 estimates.
What is the median household income in ZIP 49221?
The median household income in ZIP 49221 is $65,977, which is 14% below the national average of $76,288.
What is the average home value in ZIP 49221?
The median home value in ZIP 49221 is $170,400, which is 39% below the national average of $278,155.
What is the demographic makeup of ZIP 49221?
The largest racial group in ZIP 49221 is White at 81.1%. Hispanic or Latino residents make up 13.8% of the population.
How many businesses are in ZIP code 49221?
ZIP code 49221 has 819 business establishments employing approximately 14,453 people, according to Census Bureau ZIP Code Business Patterns (ZBP) 2023 data.
What are the main industries in ZIP code 49221?
The top industries by establishment count in ZIP 49221 are: Retail trade (138), Health care and social assistance (134), Other services (except public administration) (90). There are 17 industry sectors represented in total.
How have home values changed in ZIP code 49221?
According to the FHFA House Price Index, home values in ZIP 49221 increased by 4.8% in 2024. Since 2000, home values in this ZIP have appreciated by approximately 64%. This is a developmental index based on repeat sales and appraisal data from Fannie Mae and Freddie Mac.
What is the education level in ZIP code 49221?
In ZIP code 49221, 58.9% of residents aged 25+ have a high school diploma or higher, and 22.3% hold a bachelor's degree or higher. These figures come from the Census Bureau ACS 5-Year Estimates (2023).
What is the average commute time in ZIP 49221?
The mean commute time for workers in ZIP code 49221 is 23.7 minutes according to Census ACS data. The national average is roughly 26 minutes, so commuters here spend less time traveling to work than typical.
What percentage of residents own vs. rent in ZIP 49221?
In ZIP code 49221, approximately 71.1% of occupied housing units are owner-occupied and 28.9% are renter-occupied, based on Census ACS 2023 data.
What is the poverty rate in ZIP code 49221?
The poverty rate in ZIP code 49221 is 15.5% according to Census Bureau ACS 2023 estimates. This measures the percentage of the population living below the federal poverty threshold.

ZIP Code Research Guides

Official Data Resources for Adrian, MI

Verify and explore additional data for this area using these official government sources.

Source: U.S. Census Bureau, ACS 5-Year Estimates (2023). Business data: Source: Census ZIP Code Business Patterns (ZBP) 2023. Home value trends: Source: FHFA House Price Index (HPI), Five-Digit ZIP Codes.

PlainZIP is not affiliated with the U.S. Census Bureau or any government agency.