ZIP Code 49221
standardSource:
Adrian · Lenawee County · Michigan
- Population
- 41,310
- Median income
- $65,977
- Median home value
- $170,400
- Bachelor's or higher
- 22.3%
- Land area
- 306.7 sq mi
135/sq mi
▼ 14% vs US
higher than 40% of US ZIPs
▼ 39% vs US
higher than 34% of US ZIPs
Median age 41.1
Detroit
ZIP code 49221 in Adrian, Michigan has a population of 41,310. The median household income is $65,977, which is 14% below the national average. Median home value is $170,400, 39% below the US average. 22.3% of residents hold a bachelor's degree or higher.
ZIP code 49221 is classified by USPS as a standard delivery area and covers roughly 306.7 square miles in Adrian, Lenawee County, Michigan. The area is home to 41,310 residents, producing a population density of 135 people per square mile, and falls within the Detroit time zone. These USPS and Census boundary values drive every downstream statistic on this page, including the benchmarks that compare 49221 against Michigan and the nation.
On the economic side, the median household income for ZIP 49221 sits at $65,977 (10% below the Michigan average), while per-capita income is $31,437. The poverty rate stands at 15.5% and the unemployment rate at 4.5%. On housing, the median home value is $170,400 (22% below the state average) with median rent at $992 per month, and 71.1% of occupied units are owner-occupied, a direct signal of whether 49221 behaves more like a homeowner neighborhood or a renter-heavy ZIP.
Education and household profile round out the picture: 22.3% of adults hold a bachelor's degree or higher, the median age is 41.1, and the average commute is 24 minutes. We also surface 7 nearby ZIP codes within roughly 10 miles and 6 additional ZIPs sharing Lenawee County, so you can benchmark 49221 against its immediate geography rather than a national average alone. Every figure is sourced from the U.S. Census Bureau American Community Survey 5-Year Estimates, HUD Fair Market Rents, and FHFA Home Price Index data, no estimates, no proprietary scoring. Verify with HUD →
Top industries in ZIP 49221
Top 5 sectors by establishment count
Which industries have the most business establishments in ZIP 49221.
- Retail trade
Retail trade
138 establishments
- Health care and social assistance
Health care and social assistance
134 establishments
- Other services (except public administration)
Other services (except public administration)
90 establishments
- Accommodation and food services
Accommodation and food services
86 establishments
- Construction
Construction
67 establishments
What this shows Establishment counts come from the Census ZIP Code Business Patterns program, which counts physical business locations rather than employees or revenue.
Source: U.S. Census Bureau, American Community Survey 5-Year Estimates + ZIP Code Business Patterns + HUD FMR + FHFA HPI ACS demographics, ZBP business establishments, HUD Fair Market Rents, FHFA HPI for ZIP 49221, Adrian, MI · 2023 Census ACS 5-Year Estimates use a rolling 60-month sample for stable small-geography estimates; ZBP updated annually; HUD FMR + FHFA HPI updated quarterly/annually.
Quick Facts
41,310
Population
306.7
Area (sq mi)
135
People / sq mi
Detroit
Time Zone
standard
ZIP Type
Who lives in ZIP 49221?
41.1
Median Age
51.9%
Male
48.1%
Female
2.7%
Foreign-Born
Hispanic or Latino is an ethnicity category from the Census Bureau and may overlap with other categories above.
Source: U.S. Census Bureau, ACS 5-Year Estimates (2023)
How much do residents earn?
$65,977
Median Household Income
-10% vs state
$31,437
Per Capita Income
15.5%
Poverty Rate
4.5%
Unemployment Rate
23.7 min
Mean Commute Time
Source: U.S. Census Bureau, ACS 5-Year Estimates (2023)
What is the education profile here?
Source: U.S. Census Bureau, ACS 5-Year Estimates (2023)
What does housing look like?
17,187
Total Housing Units
15,658
Occupied Units
1,529
Vacant Units
2.34
Avg Household Size
Occupancy Type
$170,400
Median Home Value
-22% vs state
$992
Median Rent
1968
Median Year Built
Source: U.S. Census Bureau, ACS 5-Year Estimates (2023)
How have home values changed over time?
FHFA House Price Index, annual appreciation data based on repeat sales and appraisals
+4.8%
YoY Change (2024)
164
HPI Index (2000 = 100)
+64%
Total Change Since 2000
Home values in ZIP 49221 have increased 4.8% over the past year (2024). Since 2000, this ZIP has seen +64% cumulative appreciation.
| Year | Annual Change | HPI Index |
|---|---|---|
| 2020 | +3.0% | 118 |
| 2021 | +13.6% | 134 |
| 2022 | +10.6% | 148 |
| 2023 | +6.1% | 157 |
| 2024 | +4.8% | 164 |
Source: Federal Housing Finance Agency (FHFA) House Price Index, All-Transactions, Five-Digit ZIP Codes (Developmental Index). Index base = 100 in year 2000. Data through 2024. ZIP codes with few transactions may show missing values.
What businesses operate in this ZIP?
Census Bureau data shows 819 business establishments in ZIP 49221, employing approximately 14,453 people with a combined annual payroll of $671,869,000.
819
Businesses
14,453
Employees
$671.9M
Annual Payroll
17
Industry Sectors
| Industry | Establishments | % of Total |
|---|---|---|
| Retail trade | 138 | 16.9% |
| Health care and social assistance | 134 | 16.4% |
| Other services (except public administration) | 90 | 11.0% |
| Accommodation and food services | 86 | 10.5% |
| Construction | 67 | 8.2% |
| Finance and insurance | 56 | 6.8% |
| Professional, scientific, and technical services | 48 | 5.9% |
| Administrative and support and waste management and remediation services | 45 | 5.5% |
| Real estate and rental and leasing | 38 | 4.6% |
| Manufacturing | 35 | 4.3% |
| Wholesale trade | 21 | 2.6% |
| Transportation and warehousing | 14 | 1.7% |
| Educational services | 14 | 1.7% |
| Arts, entertainment, and recreation | 11 | 1.3% |
| Information | 10 | 1.2% |
| Management of companies and enterprises | 5 | 0.6% |
| Utilities | 3 | 0.4% |
Source: U.S. Census Bureau, ZIP Code Business Patterns (ZBP), 2023. Employment figures may include noise for disclosure avoidance.
Nearby ZIP Codes
Want a side-by-side? Compare 49221 vs 49287 →
More ZIP Codes in Lenawee County
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Frequently Asked Questions
What county is ZIP code 49221 in? ▼
What is the population of ZIP code 49221? ▼
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What is the demographic makeup of ZIP 49221? ▼
How many businesses are in ZIP code 49221? ▼
What are the main industries in ZIP code 49221? ▼
How have home values changed in ZIP code 49221? ▼
What is the education level in ZIP code 49221? ▼
What is the average commute time in ZIP 49221? ▼
What percentage of residents own vs. rent in ZIP 49221? ▼
What is the poverty rate in ZIP code 49221? ▼
ZIP Code Research Guides
Official Data Resources for Adrian, MI
Verify and explore additional data for this area using these official government sources.
Source: U.S. Census Bureau, ACS 5-Year Estimates (2023). Business data: Source: Census ZIP Code Business Patterns (ZBP) 2023. Home value trends: Source: FHFA House Price Index (HPI), Five-Digit ZIP Codes.
PlainZIP is not affiliated with the U.S. Census Bureau or any government agency.
Read our methodology , how this data is sourced, computed, and verified.