Residential delivery area · Texas
ZIP Code 78221: San Antonio, TX
ZIP code 78221 uses the postal name San Antonio, Texas and lies entirely in Bexar County (Census 2020 ZIP-county file). About 42,000 people live there (Census Bureau, ACS 2020-2024), the 16th most populous of San Antonio's 59 residential ZIP codes. Median household income is $63,811 (Census Bureau, ACS 2020-2024). By Census place, 47% of its land lies in San Antonio; 53% is outside any Census place.
- ACS2020-24
- Census2020
- FHFA2025
- ZBP2023
- IRS2022
- Town
- San Antonio · 59 residential ZIPs
- County
- Bexar County
- Census places
- San Antonio
- Neighborhoods
- Cassin, Earle, San Jose, Terrell Wells GeoNames
- Metro area
- San Antonio-New Braunfels, TX
- House districts
- TX-28 (69%), TX-23 (18%), TX-20 (12%) 119th Congress, by share of land
- State
- Texas
- Time zone
- Central
- Land area
- 36.3 sq mi · 1,162 people per sq mi
- PO Box ZIPs
- 24 more ZIP codes use the name San Antonio for PO boxes or single organizations
Where is ZIP code 78221?
78221 centers on 29.299°, -98.483° and covers 36.3 square miles of land plus 1.8 of water. It borders 6 ZIP codes: 78214, 78224, 78223, 78211, 78264, 78112.
The map draws ZIP code areas only. For the streets inside 78221, open its center on OpenStreetMap.
Source: U.S. Census Bureau, 2020 ZCTA cartographic boundaries and the 2023 Gazetteer (2020 ZCTAs); ZIP-to-county shares, Census places and House districts (119th Congress) from the Census 2020 relationship files (shares of land); metro area from the OMB delineation (July 2023); town name and time zone from simplemaps US ZIP Codes (CC BY 4.0); neighborhoods from the GeoNames gazetteer (CC BY 4.0), placed in this ZIP code by PlainZIP.
How does 78221 compare with the rest of San Antonio?
| Measure | 78221 | In San Antonio | In Bexar County | In TX |
|---|---|---|---|---|
| People (ACS 2020-2024) | 42,178 | 16th of 59 | 19th of 78 | 211th of 1,990 |
| Median household income | $64k | 28th of 50 | 42nd of 65 | 767th of 1,172 |
| Median home value | $171k | 41st of 54 | 52nd of 67 | 856th of 1,172 |
Its median household income is higher than in 36% of U.S. residential ZIP codes, and it is denser than 80% of all U.S. residential ZIP codes. ZIP codes at the ACS caps ($250,000 or more for household income, $2,000,000 or more for home value) share the top rank.
Source: U.S. Census Bureau, ACS 2020-2024 5-year estimates (B01003, B19013, B25077); ranks by PlainZIP over residential ZIP codes (ZCTAs).
How many people live in 78221?
The 2020 Census counted 39,779 people in 78221; the ACS, which samples households over 2020-2024, estimates 42,178. Its boundary changed between the 2010 and 2020 censuses, so the two counts are not compared.
- People, ACS 2020-2024
- 42,178
- 2020 Census count
- 39,779
- Households
- 13,264
- Median age
- 34.0
Source: U.S. Census Bureau, ACS 2020-2024 5-year estimates (B01003, B01002, B11001); 2020 Census (DHC P1); 2010 Census (SF1 P1).
Who lives in 78221?
Of the 42,178 people the ACS estimates in 78221, 26.6% are under 18 and 11.9% are 65 or older. The largest group by race and Hispanic origin is Hispanic or Latino (87.7%), then White (not Hispanic) (10.3%).
- Under 1826.6%
- 18 to 6461.6%
- 65 and older11.9%
- Hispanic or Latino87.7%
- White, not Hispanic10.3%
- Other or two or more1.2%
- Black, not Hispanic0.4%
- Asian, not Hispanic0.3%
Source: U.S. Census Bureau, ACS 2020-2024 5-year estimates (B01001 age by sex, B03002 Hispanic or Latino origin by race); shares of the estimated population, small ZIP codes carry wide margins.
What do households in 78221 earn?
Median household income is $63,811 (ACS 2020-2024), the 42nd highest of the 65 ranked ZIP codes in Bexar County.
- Median household income
- $63,811
- Income per person
- $24,423
- Below the poverty line
- 17.3%
- Unemployed (of the labor force)
- 6.5%
- Adults 25+ with a bachelor's degree
- 12.2%
- Adjusted gross income per tax return, 2022
- $42,21717,580 returns; wages 84% of AGI (IRS)
Source: U.S. Census Bureau, ACS 2020-2024 and 2015-2019 5-year estimates (B19013, B19301, B17001, B23025, B15003; 2015-2019 dollars converted with the BLS CPI-U, 1.22699); IRS Statistics of Income, ZIP code data, tax year 2022 (adjusted gross income per return, filed under the address on the return).
What are homes worth in 78221?
FHFA's house price index for 78221, built from repeat sales and appraisals of the same homes, rose 96% from 2015 to 2025 and rose 26% from 2020 to 2025, and moved −17.4% in 2025.
- Median home value (owners' estimate)
- $171,200
- Median gross rent
- $1,228
- Homes owned by their occupants
- 70.2%
- Housing units
- 15,141
Source: U.S. Census Bureau, ACS 2020-2024 5-year estimates (B25077, B25064, B25003, B25001); FHFA House Price Index, annual five-digit ZIP, updated 2026-03-31.
What businesses are in 78221?
513 business establishments had a location in this ZIP code in 2023, 28 more than in 2018; the most are in retail trade (ZIP Code Business Patterns).
- Retail trade106
- Finance and insurance73
- Health care and social assistance68
- Accommodation and food services63
- Other services (except public administration)56
- Construction30
Source: U.S. Census Bureau, ZIP Code Business Patterns 2023 and 2018 (establishments with paid employees, by the business's ZIP code).
Which ZIP codes are next to 78221?
| ZIP | Town | People | Household income | Distance |
|---|---|---|---|---|
| 78214 | San Antonio | 22,118 | $45k | 3.6 mi |
| 78224 | San Antonio | 22,232 | $60k | 3.9 mi |
| 78223 | San Antonio | 58,983 | $52k | 5.8 mi |
| 78211 | San Antonio | 30,857 | $55k | 6.1 mi |
| 78264 | San Antonio | 11,841 | $54k | 6.9 mi |
| 78112 | Elmendorf | 9,769 | $55k | 9.4 mi |
| 78235 | San Antonio | 2,304 | $63k | 4.1 mi (near) |
| 78225 | San Antonio | 13,104 | $47k | 6.7 mi (near) |
| 78210 | San Antonio | 34,940 | $55k | 6.8 mi (near) |
Source: PlainZIP from the Census 2020 ZCTA boundaries (shared edges) and internal points; figures ACS 2020-2024.